N-Docosahexaenoyl Dopamine, an Endocannabinoid-like Conjugate of Dopamine and the n-3 Fatty Acid Docosahexaenoic Acid, Attenuates Lipopolysaccharide-Induced Activation of Microglia and Macrophages via COX-2

Auteurs YA Wang , P. Plastina , Jean-Paul Vincken , Renate Jansen , Michiel Balvers , Jean Paul ten Klooster , Harry Gruppen , Renger Witkamp , Jocelijn Meijerink
Gepubliceerd in ACS Chemical Neuroscience
Publicatiedatum 2017
Lectoraat Innovative Testing in Life Sciences & Chemistry
Soort publicatie Artikel


https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.6b00298 From teh publisher: "Several studies indicate that the n-3 long-chain polyunsaturated fatty acid docosahexaenoic acid (DHA) contributes to an attenuated inflammatory status in the development of neurodegenerative disorders, such as Alzheimer’s and Parkinson’s disease. To explain these effects, different mechanisms are being proposed, including those involving endocannabinoids and related signaling molecules. Many of these compounds belong to the fatty acid amides, conjugates of fatty acids with biogenic amines. Conjugates of DHA with ethanolamine or serotonin have previously been shown to possess anti-inflammatory and potentially neuroprotective properties. Here, we synthesized another amine conjugate of DHA, N-docosahexaenoyl dopamine (DHDA), and tested its immune-modulatory properties in both RAW 264.7 macrophages and BV-2 microglial cells."

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Taal Engels
Gepubliceerd in ACS Chemical Neuroscience
ResearchComponents.DetailedInformation.YearAndVolume 8 3
Trefwoorden cyclooxygenase-2
Paginabereik 548-557

Innovative Testing in Life Sciences and Chemistry